Elevated Lipoprotein(a) Levels and Atrial Fibrillation: A Systematic Review

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Date

2023

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Journal of lipid and atherosclerosis

Abstract

Description

Objective: The role of lipoprotein(a) (Lp[a]) as a possibly causal risk factor for atherosclerotic cardiovascular disease has been well established. However, the clinical evidence regarding the association between Lp(a) levels and atrial fibrillation (AF) remains limited and inconsistent. This study aimed to analyze the association between elevated Lp(a) levels or single-nucleotide polymorphisms (SNPs) related to high levels of Lp(a) and AF. Methods: This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A literature search was performed to identify studies that evaluated the association between Lp(a) levels or SNPs related to high levels of Lp(a) and AF. Observational studies with a cross-sectional, casecontrol, or cohort design were included in this systematic review, without limitations according to language, country, or publication type. Results: Eleven observational studies including 1,246,817 patients were eligible for this systematic review. Two cross-sectional studies, 5 prospective/retrospective cohort studies, and 4 Mendelian randomization studies were analyzed. Two cross-sectional studies that compared Lp(a) levels between patients with and without AF showed conflicting results. Cohort studies that evaluated the incidence of AF according to Lp(a) levels showed different results: no association (3 studies), a positive association (1 study), and an inverse relationship (1 study). Finally, Mendelian randomization studies also showed heterogeneous results (positive association: 2 studies; inverse association: 1 study; no association: 1 study). Conclusion: Although there could be an association between Lp(a) levels and AF, the results of the studies published to date are contradictory and not yet definitive. Therefore, further research should clarify this issue.
Fil: Masson, Walter. Department of Cardiology. Hospital Italiano de Buenos Aires; Argentina.
Fil: Barbagelato, Leandro. Department of Cardiology. Hospital Italiano de Buenos Aires; Argentina.
Fil: Nogueira, Juan P. Universidad Nacional de Formosa. Faculty of Health Sciences. Department of Endocrinology. Nutrition and Metabolism Research Center; Argentina
Fil: Nogueira, Juan P. International University of the Americas; Costa Rica.
Fil: Corral, Pablo. Universidad FASTA. Facultad de Ciencias Médicas; Argentina.
Fil: Lavalle-Cobo, Augusto. Department of Cardiology. Sanatorio Finochietto; Argentina.
Fil: Romeo, Francisco J. Department of Medicine. Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside; Estados Unidos.
Fil: Romeo, Francisco J. Department of Cardiology. University of Miami/Jackson Memorial Hospital; Estados Unidos.

Keywords

Lipoproteína (a) , Fibrilación auricular , Revisión sistemática , Dislipidemia

Citation

Masson, W., Barbagelata, L., Nogueira, J. P., Corral, P., Lavalle-Cobo, A., & Romeo, F. J. (2023). Elevated Lipoprotein(a) Levels and Atrial Fibrillation: A Systematic Review. Journal of lipid and atherosclerosis, 12(3), 267–276. https://doi.org/10.12997/jla.2023.12.3.267

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https://dspace.ufasta.edu.ar/handle/123456789/87938

item.page.issn

2288-2561

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Journal of lipid and atherosclerosis, 12(3), 267–276.

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